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Alternately, incensing number of evidences have confirmed or validated the formation of selenylsulfide (-Se-S-) intermediate and the involvement of thioldisulfide exchange during the GPx cycle [17,18,19]
PMID 31451866
TCR-induced activation of mTORC1 and metabolic signaling pathways requires SLC1A5-dependent uptake of glutamine
These distinctions highlight that the mode of GSH depletion, i.e., via acute blockade of synthesis versus more gradual enhanced degradation, can differentially influence the oxidative stress response, secondary transcriptional programs, and systemic physiology
